Detalhe da pesquisa
1.
Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider.
Proc Natl Acad Sci U S A
; 119(5)2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35074873
2.
Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead.
Proc Natl Acad Sci U S A
; 118(8)2021 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33602819
3.
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.
Proc Natl Acad Sci U S A
; 114(14): 3750-3755, 2017 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28320941
4.
Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans.
Cell Mol Life Sci
; 75(23): 4465-4478, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30069700
5.
Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction.
Eur Heart J
; 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38095341
6.
Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2.
Angew Chem Int Ed Engl
; 53(4): 1017-20, 2014 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24323786
7.
The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation.
Biochem Pharmacol
; : 116175, 2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38552850
8.
Hi1a Improves Sensorimotor Deficit following Endothelin-1-Induced Stroke in Rats but Does Not Improve Functional Outcomes following Filament-Induced Stroke in Mice.
ACS Pharmacol Transl Sci
; 7(4): 1043-1054, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38638162
9.
Evaluation of Peptide Ligation Strategies for the Synthesis of the Bivalent Acid-Sensing Ion Channel Inhibitor Hi1a.
Org Lett
; 25(24): 4439-4444, 2023 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37306339
10.
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function.
Nat Commun
; 14(1): 2442, 2023 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37117223
11.
Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3.
Mar Drugs
; 10(7): 1605-1618, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22851929
12.
Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3.
Mar Drugs
; 10(7): 1511-1527, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22851922
13.
A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a.
Mol Pharmacol
; 80(5): 796-808, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21825095
14.
Venomics: a new paradigm for natural products-based drug discovery.
Amino Acids
; 40(1): 15-28, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20177945
15.
Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System.
Front Cell Neurosci
; 15: 738043, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34602982
16.
Total Synthesis of the Spider-Venom Peptide Hi1a.
Org Lett
; 23(21): 8375-8379, 2021 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34632783
17.
The Diversity of Venom: The Importance of Behavior and Venom System Morphology in Understanding Its Ecology and Evolution.
Toxins (Basel)
; 11(11)2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31739590
18.
The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: Importance of interactions at the channel subunit interface and potential for engineering selective analogues.
Biochem Pharmacol
; 163: 381-390, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30849303
19.
D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels.
Toxins (Basel)
; 11(4)2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30939844
20.
Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels.
Biochem Pharmacol
; 164: 342-348, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31028742